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4F-PHP may also go by the name 4-fluro-pyrrolidinohexiophenone. It is an analogue of the compound alpha-pyrrolidinohexiophenone with 4F-PHP distinguished from its parent compound by having the aromatic ring fluorinated in the para position.
Fluorination of drug compounds can sometimes increase bioavailability and lipophilicity and the highly electronegative character of fluorine can change the topographical charge of the molecule interfering with metabolism and giving the compound a longer half life. The electronegative fluorine atom should make the carbonyl less polar and reduce reactivity of the compound.
4F-PHP belongs to the class of chemicals known as substituted cathinones.
The substituted cathinones are a series of compounds which feature a phenethylamine backbone with a ketone at the beta carbon and various alkyl moieties substituted at the alpha carbon adjacent to the amine. 4F-PVP and α-PHP have a butyl substitute at the alpha carbon. This confers increased lipohpilicity to these particular cathinones. The nitrogen itself is transformed in to a pyrrolidine moiety as it forms a five member ring with four other carbons.
Many of the cathinone compounds have stimulatory effects when consumed. Some induce states of euphoria and some act as entactogens. They are related to the chemical compound cathinone, a substance derived from the plant Khat which is native to the horn of Africa.
Khat is an ethnobotanical with a long history of use by indigenous people. The method of administration was to chew on the leaf, releasing the cathinone compound to induce the desired pleasant stimulatory effect. Substituted cathinones by contrast have a much shorter period of human usage with use of compounds like mephedrone and methylone first being reported in the last 15 years. These compounds reached widespread popularity due to availability online and reported effects similar to the traditional psychoactives like cocaine, MDMA and amphetamine.
Due to increasingly restrictive legislation prohibiting the sale of these compounds new generations of substituted cathinones have emerged including MDPV, α-PVP, α-PHP and 4F-PVP. Changes in structure can have large differences in subjective effects, duration or action, side effects and toxicity.
Owing to the wide variety of emerging cathinones there is often a paucity of information regarding the effect profiles of many members of this class of drugs. Continual modifications are made in order to attempt to circumvent legislation.
α-PHP, a close relation of 4F-PHP, was reported to be an effective stimulant that induced a rush, feelings of alertness and euphoria. Perhaps owing to the similarity 4F-PHP may have similar effects.
4F-PHP is an extremely new compound. As such there is no research in to the pharmacological and toxicological profile of this compound and its potentially deleterious effects when used in humans.
This compound is not for consumption by animals or humans.
Subjective and unverifiable online reports suggest this compound is reasonably potent and induces euphoria, rush and stimulation.
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